L-carnitine does not ameliorate asparaginase-associated hepatotoxicity in a C57BL6 mouse model
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Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration
Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models of neurological diseases. However, it remained unknown whether minocycline is effective to prevent neuron loss. To systematically evaluate its effects, minocycline was used to treat Dicer conditional knockout (cKO) mice wh...
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Fig. 1. Abdominal computed tomography showed a hepatomegaly and hepatosteatosis. REFERENCES 1. Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054-61. 2. Scott LM. The JAK2 exon 12 mutations: a comprehensive review. Am J Hematol 2011;86:668-76. 3. Darwish Murad S, Plessier A, Hernandez-Guerra M, et al...
متن کاملL-carnitine ameliorates L-asparaginase-induced acute liver toxicity in steatotic rat livers.
BACKGROUND Chemotherapy with L-asparaginase is associated with hepatotoxicity resulting in organ dysfunction in patients with preexisting liver disorders. This study investigated the protective effect of L-carnitine during chemotherapy in a steatotic rat liver model. METHODS Livers from nonsteatotic and steatotic rats were tested in an isolated liver reperfusion model adding L-asparaginase an...
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Sydney R. Coffey 1, Robert M. Bragg 1, Shawn Minnig 1, Seth A. Ament 2,3, Anne Glickenhaus 1, Daniel Shelnut 4, José M. Carrillo 1, Dominic D. Shuttleworth 1, Julie-Anne Rodier 5, Kimihiro Noguchi 4, C. Frank Bennett 6, Nathan D. Price 2, Holly B. Kordasiewicz 6 and Jeffrey B. Carroll 1,* 1 Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, US...
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ژورنال
عنوان ژورنال: Leukemia & Lymphoma
سال: 2019
ISSN: 1042-8194,1029-2403
DOI: 10.1080/10428194.2019.1571198